Pfizer did not confirm the authenticity of the study document. Its lead authors are Sharon Alroy-Preis, head of public health for Israel’s health ministry, and Eric Haas, a ministry researcher. In addition, the study was carried out by a team of eight Pfizer researchers, including epidemiologists Farid Khan and John McLaughlin and the company’s global medical lead for covid vaccines, David Swerdlow, an infectious disease expert previously with the US Centers for Disease Control and Prevention.
The research represents the first joint report by the health ministry and Pfizer since they reached an agreement earlier this year for Israel to share vaccination data in return for a steady supply of doses.
The cooperation is part of a wider effort by Pfizer to track how its vaccine, named Comirnaty, works in large populations. The company told MIT Technology Review earlier this week that it is studying “the vaccine’s real-world effectiveness at several locations worldwide, including Israel,” and “particularly looking at real-world data from Israel to understand any potential impact of the vaccine to protect against covid-19 arising from emerging variants.” Pfizer’s vaccine, like one from Moderna, another mRNA vaccine authorized for use in the US and Europe, uses two injections of messenger RNA carrying information about the virus to train people’s immune system to recognize and combat the infection.
The new findings are broadly consistent with separate announcements in recent days from two of Israel’s large health organizations, Maccabi Healthcare Services and Clalit Health Services, which together care for 80% of Israelis.
On February 14, Ran Balicer, chief of innovation and research at Clalit, the largest Israeli HMO, said that evidence collected on 1.2 million members “shows unequivocally that Pfizer’s coronavirus vaccine is extremely effective in the real world a week after the second dose.”
Other analyses suggest that serious infections and deaths have fallen among older Israelis, who got the vaccine first, but not among those younger than 44 who have not been vaccinated.
The Israeli report describes observations made during three weeks in January and February when researchers were able to compare health records of unvaccinated people and people who had gotten their second shot more than a week before. They then compared the groups for five covid-19 outcomes: infection, symptoms, hospitalizations, critical hospitalization, and death. The unpublished study says the vaccine was around 93% effective in preventing symptomatic covid-19. Pfizer and its partner, the German biotechnology firm BioNTech, had found 95% effectiveness in their clinical trials carried out in 2020. The country-wide study was also able to show that hospitalizations and deaths dropped by similar amounts in the vaccinated group.
Because Israel tests people fairly comprehensively, the researchers were also able to estimate that the vaccine was 89.4% effective in preventing any detectable infection at all, including asymptomatic infections.
That finding, which is new, suggests that the vaccine could strongly suppress transmission of the virus between people and could help bring the outbreak to an end, a possibility Pfizer and the Israeli researchers say they are closely watching. “Israel provides a unique opportunity to observe the nation-wide impact of an increasing prevalence of immunity on Sars-Cov-2 transmission,” the authors wrote. Eric Topol, a doctor at Scripps Research in California, who reviewed the document, says that “the blocking of infections here speaks to the vaccine’s impact on asymptomatic transmission, which we’ve been unsure about.”
Investing in women pays off
“Starting a business is a privilege,” says Burton O’Toole, who worked at various startups before launching and later selling AdMass, her own marketing technology company. The company gave her access to the HearstLab program in 2016, but she soon discovered that she preferred the investment aspect and became a vice president at HearstLab a year later. “To empower some of the smartest women to do what they love is great,” she says. But in addition to rooting for women, Burton O’Toole loves the work because it’s a great market opportunity.
“Research shows female-led teams see two and a half times higher returns compared to male-led teams,” she says, adding that women and people of color tend to build more diverse teams and therefore benefit from varied viewpoints and perspectives. She also explains that companies with women on their founding teams are likely to get acquired or go public sooner. “Despite results like this, just 2.3% of venture capital funding goes to teams founded by women. It’s still amazing to me that more investors aren’t taking this data more seriously,” she says.
Burton O’Toole—who earned a BS from Duke in 2007 before getting an MS and PhD from MIT, all in mechanical engineering—has been a “data nerd” since she can remember. In high school she wanted to become an actuary. “Ten years ago, I never could have imagined this work; I like the idea of doing something in 10 more years I couldn’t imagine now,” she says.
When starting a business, Burton O’Toole says, “women tend to want all their ducks in a row before they act. They say, ‘I’ll do it when I get this promotion, have enough money, finish this project.’ But there’s only one good way. Make the jump.”
Preparing for disasters, before it’s too late
All too often, the work of developing global disaster and climate resiliency happens when disaster—such as a hurricane, earthquake, or tsunami—has already ravaged entire cities and torn communities apart. But Elizabeth Petheo, MBA ’14, says that recently her work has been focused on preparedness.
It’s hard to get attention for preparedness efforts, explains Petheo, a principal at Miyamoto International, an engineering and disaster risk reduction consulting firm. “You can always get a lot of attention when there’s a disaster event, but at that point it’s too late,” she adds.
Petheo leads the firm’s projects and partnerships in the Asia-Pacific region and advises globally on international development and humanitarian assistance. She also works on preparedness in the Asia-Pacific region with the United States Agency for International Development.
“We’re doing programming on the engagement of the private sector in disaster risk management in Indonesia, which is a very disaster-prone country,” she says. “Smaller and medium-sized businesses are important contributors to job creation and economic development. When they go down, the impact on lives, livelihoods, and the community’s ability to respond and recover effectively is extreme. We work to strengthen their own understanding of their risk and that of their surrounding community, lead them through an action-planning process to build resilience, and link that with larger policy initiatives at the national level.”
Petheo came to MIT with international leadership experience, having managed high-profile global development and risk mitigation initiatives at the World Bank in Washington, DC, as well as with US government agencies and international organizations leading major global humanitarian responses and teams in Sri Lanka and Haiti. But she says her time at Sloan helped her become prepared for this next phase in her career. “Sloan was the experience that put all the pieces together,” she says.
Petheo has maintained strong connections with MIT. In 2018, she received the Margaret L.A. MacVicar ’65, ScD ’67, Award in recognition of her role starting and leading the MIT Sloan Club in Washington, DC, and her work as an inaugural member of the Graduate Alumni Council (GAC). She is also a member of the Friends of the MIT Priscilla King Gray Public Service Center.
“I believe deeply in the power and impact of the Institute’s work and people,” she says. “The moment I graduated, my thought process was, ‘How can I give back, and how can I continue to strengthen the experience of those who will come after me?’”
The Download: a curb on climate action, and post-Roe period tracking
Why’s it so controversial?: Geoengineering was long a taboo topic among scientists, and some argue it should remain one. There are questions about its potential environmental side effects, and concerns that the impacts will be felt unevenly across the globe. Some feel it’s too dangerous to ever try or even to investigate, arguing that just talking about the possibility could weaken the need to address the underlying causes of climate change.
But it’s going ahead?: Despite the concerns, as the threat of climate change grows and major nations fail to make rapid progress on emissions, growing numbers of experts are seriously exploring the potential effects of these approaches. Read the full story.
I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.
1 The belief that AI is alive refuses to die
People want to believe the models are sentient, even when their creators deny it. (Reuters)
+ It’s unsurprising wild religious beliefs find a home in Silicon Valley. (Vox)
+ AI systems are being trained twice as quickly as they were just last year. (Spectrum IEEE)
2 The FBI added the missing cryptoqueen to its most-wanted list
It’s offering a $100,000 reward for information leading to Ruja Ignatova, whose crypto scheme defrauded victims out of more than $4 billion. (BBC)
+ A new documentary on the crypto Ponzi scheme is in the works. (Variety)
3 Social media platforms turn a blind eye to dodgy telehealth ads
Which has played a part in the prescription drugs abuse boom. (Protocol)
+ The doctor will Zoom you now. (MIT Technology Review)
4 We’re addicted to China’s lithium batteries
Which isn’t great news for other countries building electric cars. (Wired $)
+ This battery uses a new anode that lasts 20 times longer than lithium. (Spectrum IEEE)
+ Quantum batteries could, in theory, allow us to drive a million miles between charges. (The Next Web)
5 Far-right extremists are communicating over radio to avoid detection
Making it harder to monitor them and their violent activities. (Slate $)
+ Many of the rioters who stormed the Capitol were carrying radio equipment. (The Guardian)
6 Bro culture has no place in space 🚀
So says NASA’s former deputy administrator, who’s sick and tired of misogyny in the sector. (CNN)
7 A US crypto exchange is gaining traction in Venezuela
It’s helping its growing community battle hyperinflation, but isn’t as decentralized as they believe it to be. (Rest of World)
+ The vast majority of NFT players won’t be around in a decade. (Vox)
+ Exchange Coinbase is working with ICE to track and identify crypto users. (The Intercept)
+ If RadioShack’s edgy tweets shock you, don’t forget it’s a crypto firm now. (NY Mag)
8 It’s time we learned to love our swamps
Draining them prevents them from absorbing CO2 and filtering out our waste. (New Yorker $)
+ The architect making friends with flooding. (MIT Technology Review)
9 Robots love drawing too 🖍️
Though I’ll bet they don’t get as frustrated as we do when they mess up. (Input)
10 The risky world of teenage brains
Making potentially dangerous decisions is an important part of adolescence, and our brains reflect that. (Knowable Magazine)
Quote of the day
“They shamelessly celebrate an all-inclusive pool party while we can’t even pay our rent!”