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Tackling our biggest problems

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The Download: introducing the Hard Problems issue


We have employed it to broadcast hateful rhetoric and divisive ideologies. We have fine-tuned our machines to kill each other in ever greater numbers and with ever more efficiency. It is our technology that took the carbon from out of the ground and put it in the sky. Our technology that poisoned the water and the air, that made deserts out of forests, and that wiped entire species off the planet. 

Technology is an engine for problems, for solving them and for creating entirely new ones—and then we perversely turn to even newer technologies to try to solve those. In this issue, we step back from this cycle. We explore big questions and hard problems and ask: What role can—and should—technology play going forward?

Our cover is inspired by Douglas Main’s terrifying story on plastics. There’s an adage that says every piece of plastic ever made still exists. While that isn’t entirely true, as Main vividly describes, it is pretty darn close. We’re not reducing how much is made—precisely the opposite. Reuse is negligible. Recycling isn’t working. Meanwhile, plastic is absolutely everywhere, and in absolutely everything, including our own bodies. What are we going to do about it? 

AI epitomizes the sometimes fraught relationship we have with technology. It has the potential to massively benefit society—and yet it could cause incalculable harm if we get it wrong. As its development races ahead, Grace Huckins has written a powerful, even poetic exploration of AI consciousness. What would it take, and what would it mean, for an AI to become conscious? How would we know? What would we owe it? 

David W. Brown takes on the challenge of spacecraft design and the struggle to make smaller, cheaper missions that can still tell us meaningful new things about the solar system. If we are going to make the most of the resources we devote to space exploration, we’ll have to grapple with the hard limits of physics—and think hard about what we can, and want to, do.

Some of our hardest problems come down to human nature, and our capacity and sometimes outright desire for conflict. Social media and online communications are lousy with trolling, disinformation, harassment, and hate speech. Katie Notopoulos argues that the solution for much of this is to end our fixation with free services and move to smaller, distributed platforms that put more power in users’ hands. 

One hard problem most of us have likely faced is the experience of interacting with government services online. A decade after the famously botched launch of Healthcare.gov, Tate Ryan-Mosley explores why it is still so hard for the government to get tech right. Her reporting takes us to New York City, which has had some manner of success—in part by going with the lowest tech possible. 

And finally, we asked some of the smartest minds out there what they consider the biggest problems that aren’t getting enough attention right now. You’ll find their responses, and many more online at techreview.com/hardproblems.

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These robots know when to ask for help

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These robots know when to ask for help


A new training model, dubbed “KnowNo,” aims to address this problem by teaching robots to ask for our help when orders are unclear. At the same time, it ensures they seek clarification only when necessary, minimizing needless back-and-forth. The result is a smart assistant that tries to make sure it understands what you want without bothering you too much.

Andy Zeng, a research scientist at Google DeepMind who helped develop the new technique, says that while robots can be powerful in many specific scenarios, they are often bad at generalized tasks that require common sense.

For example, when asked to bring you a Coke, the robot needs to first understand that it needs to go into the kitchen, look for the refrigerator, and open the fridge door. Conventionally, these smaller substeps had to be manually programmed, because otherwise the robot would not know that people usually keep their drinks in the kitchen.

That’s something large language models (LLMs) could help to fix, because they have a lot of common-sense knowledge baked in, says Zeng. 

Now when the robot is asked to bring a Coke, an LLM, which has a generalized understanding of the world, can generate a step-by-step guide for the robot to follow.

The problem with LLMs, though, is that there’s no way to guarantee that their instructions are possible for the robot to execute. Maybe the person doesn’t have a refrigerator in the kitchen, or the fridge door handle is broken. In these situations, robots need to ask humans for help.

KnowNo makes that possible by combining large language models with statistical tools that quantify confidence levels. 

When given an ambiguous instruction like “Put the bowl in the microwave,” KnowNo first generates multiple possible next actions using the language model. Then it creates a confidence score predicting the likelihood that each potential choice is the best one.

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The Download: inside the first CRISPR treatment, and smarter robots

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The Download: inside the first CRISPR treatment, and smarter robots


The news: A new robot training model, dubbed “KnowNo,” aims to teach robots to ask for our help when orders are unclear. At the same time, it ensures they seek clarification only when necessary, minimizing needless back-and-forth. The result is a smart assistant that tries to make sure it understands what you want without bothering you too much.

Why it matters: While robots can be powerful in many specific scenarios, they are often bad at generalized tasks that require common sense. That’s something large language models could help to fix, because they have a lot of common-sense knowledge baked in. Read the full story.

—June Kim

Medical microrobots that travel inside the body are (still) on their way

The human body is a labyrinth of vessels and tubing, full of barriers that are difficult to break through. That poses a serious hurdle for doctors. Illness is often caused by problems that are hard to visualize and difficult to access. But imagine if we could deploy armies of tiny robots into the body to do the job for us. They could break up hard-to-reach clots, deliver drugs to even the most inaccessible tumors, and even help guide embryos toward implantation.

We’ve been hearing about the use of tiny robots in medicine for years, maybe even decades. And they’re still not here. But experts are adamant that medical microbots are finally coming, and that they could be a game changer for a number of serious diseases. Read the full story.

—Cassandra Willyard

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5 things we didn’t put on our 2024 list of 10 Breakthrough Technologies

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5 things we didn’t put on our 2024 list of 10 Breakthrough Technologies


We haven’t always been right (RIP, Baxter), but we’ve often been early to spot important areas of progress (we put natural-language processing on our very first list in 2001; today this technology underpins large language models and generative AI tools like ChatGPT).  

Every year, our reporters and editors nominate technologies that they think deserve a spot, and we spend weeks debating which ones should make the cut. Here are some of the technologies we didn’t pick this time—and why we’ve left them off, for now. 

New drugs for Alzheimer’s disease

Alzmeiher’s patients have long lacked treatment options. Several new drugs have now been proved to slow cognitive decline, albeit modestly, by clearing out harmful plaques in the brain. In July, the FDA approved Leqembi by Eisai and Biogen, and Eli Lilly’s donanemab could soon be next. But the drugs come with serious side effects, including brain swelling and bleeding, which can be fatal in some cases. Plus, they’re hard to administer—patients receive doses via an IV and must receive regular MRIs to check for brain swelling. These drawbacks gave us pause. 

Sustainable aviation fuel 

Alternative jet fuels made from cooking oil, leftover animal fats, or agricultural waste could reduce emissions from flying. They have been in development for years, and scientists are making steady progress, with several recent demonstration flights. But production and use will need to ramp up significantly for these fuels to make a meaningful climate impact. While they do look promising, there wasn’t a key moment or “breakthrough” that merited a spot for sustainable aviation fuels on this year’s list.  

Solar geoengineering

One way to counteract global warming could be to release particles into the stratosphere that reflect the sun’s energy and cool the planet. That idea is highly controversial within the scientific community, but a few researchers and companies have begun exploring whether it’s possible by launching a series of small-scale high-flying tests. One such launch prompted Mexico to ban solar geoengineering experiments earlier this year. It’s not really clear where geoengineering will go from here or whether these early efforts will stall out. Amid that uncertainty, we decided to hold off for now. 

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