The version used in Maryland came from a pig with 10 gene modifications developed by Revivicor, a subsidiary of United Therapeutics.
Following promising tests of such pig organs in baboons, three US transplant teams launched the first human studies starting in late 2021. Surgeons at New York University and the University of Alabama each attached pig kidneys to brain-dead people, but the University of Maryland went a step further when Griffith stitched a pig heart into Bennett’s chest in early January.
Transferring pig viruses to humans has been a worry—some fear xenotransplantation could set off a pandemic if a virus were to adapt inside a patient’s body and then spread to doctors and nurses. The concern could be serious enough to require lifelong monitoring for patients.
However, the specific type of virus found in Bennett’s donor heart is not believed capable of infecting human cells, says Jay Fishman, a specialist in transplant infections at Massachusetts General Hospital. Fishman thinks there is “no real risk to humans” of its spreading further.
Instead, the problem is that pig cytomegalovirus is linked to reactions that can damage the organ and the patient—with catastrophic results. Two years ago, for instance, German researchers reported that pig hearts transplanted into baboons lasted only a couple of weeks if the virus was present, while organs free from the infection could survive more than half a year.
Those researchers said they found “astonishingly high” virus levels in pig hearts removed from baboons. They think the virus could go haywire not just because the baboons’ immune systems were suppressed with drugs, but also because the pig immune system was no longer there to keep the virus in check. It “seems very likely the same may happen in humans,” they warned at the time.
Pig heart recipient David Bennett Sr. with his transplant doctor, Bartley Griffith of the University of Maryland.
UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE
Joachim Denner of the Institute of Virology at the Free University of Berlin, who led that study, says the solution to the problem is more accurate testing. The US team appears to have tested the pig’s snout for the virus, but often it is lurking deeper in the tissues.
“It’s a latent virus and hard to detect,” says Denner. “But if you test the animal better, it will not happen. The virus can be detected and easily removed from pig populations, but unfortunately they didn’t use a good assay and didn’t detect the virus, and this was the reason. The donor pig was infected, and the virus was transmitted by the transplant.”
Denner says he still thinks the experiment was a “great success.” For instance, the first human-to-human heart transplant, in 1967, lasted only 18 days and, two years later, one in Germany endured just 27 hours.
Denner says that Bennett’s death cannot be blamed on the virus alone. “This patient was very, very, very ill. Do not forget that,” he says. “Maybe the virus contributed, but it was not the sole reason.”
Cause of death?
Bennett’s cause of death matters, because if his heart failed as the result of immune rejection, researchers might need to return to the drawing board. Instead, it’s now expected that companies like United Therapeutics and eGenesis, or academics working with them, will launch clinical trials of their pig organs within a year or two.
Bennett was offered a pig heart after Griffith applied to the US Food and Drug Administration for special permission to try an animal organ in a one-off transplant. He was considered a good candidate for the daring attempt because he was nearing death from heart failure and was ineligible for a scarce human heart for transplant owing to a history of disregarding medical advice.
The Advanced Research Projects Agency for Energy (ARPA-E) funds high-risk, high-reward energy research projects, and each year the agency hosts a summit where funding recipients and other researchers and companies in energy can gather to talk about what’s new in the field.
As I listened to presentations, met with researchers, and—especially—wandered around the showcase, I often had a vague feeling of whiplash. Standing at one booth trying to wrap my head around how we might measure carbon stored by plants, I would look over and see another group focused on making nuclear fusion a more practical way to power the world.
There are plenty of tried-and-true solutions that can begin to address climate change right now: wind and solar power are being deployed at massive scales, electric vehicles are coming to the mainstream, and new technologies are helping companies make even fossil-fuel production less polluting. But as we knock out the easy wins, we’ll also need to get creative to tackle harder-to-solve sectors and reach net-zero emissions. Here are a few intriguing projects from the ARPA-E showcase that caught my eye.
Vaporized rocks
“I heard you have rocks here!” I exclaimed as I approached the Quaise Energy station.
Quaise’s booth featured a screen flashing through some fast facts and demonstration videos. And sure enough, laid out on the table were two slabs of rock. They looked a bit worse for wear, each sporting a hole about the size of a quarter in the middle, singed around the edges.
These rocks earned their scorch marks in service of a big goal: making geothermal power possible anywhere. Today, the high temperatures needed to generate electricity using heat from the Earth are only accessible close to the surface in certain places on the planet, like Iceland or the western US.
Geothermal power could in theory be deployed anywhere, if we could drill deep enough. Getting there won’t be easy, though, and could require drilling 20 kilometers (12 miles) beneath the surface. That’s deeper than any oil and gas drilling done today.
Rather than grinding through layers of granite with conventional drilling technology, Quaise plans to get through the more obstinate parts of the Earth’s crust by using high-powered millimeter waves to vaporize rock. (It’s sort of like lasers, but not quite.)
Annika Hauptvogel, head of technology and innovation management at Siemens, describes the industrial metaverse as “immersive, making users feel as if they’re in a real environment; collaborative in real time; open enough for different applications to seamlessly interact; and trusted by the individuals and businesses that participate”—far more than simply a digital world.
The industrial metaverse will revolutionize the way work is done, but it will also unlock significant new value for business and societies. By allowing businesses to model, prototype, and test dozens, hundreds, or millions of design iterations in real time and in an immersive, physics-based environment before committing physical and human resources to a project, industrial metaverse tools will usher in a new era of solving real-world problems digitally.
“The real world is very messy, noisy, and sometimes hard to really understand,” says Danny Lange, senior vice president of artificial intelligence at Unity Technologies, a leading platform for creating and growing real-time 3-D content. “The idea of the industrial metaverse is to create a cleaner connection between the real world and the virtual world, because the virtual world is so much easier and cheaper to work with.”
While real-life applications of the consumer metaverse are still developing, industrial metaverse use cases are purpose-driven, well aligned with real-world problems and business imperatives. The resource efficiencies enabled by industrial metaverse solutions may increase business competitiveness while also continually driving progress toward the sustainability, resilience, decarbonization, and dematerialization goals that are essential to human flourishing.
This report explores what it will take to create the industrial metaverse, its potential impacts on business and society, the challenges ahead, and innovative use cases that will shape the future. Its key findings are as follows:
• The industrial metaverse will bring together the digital and real worlds. It will enable a constant exchange of information, data, and decisions and empower industries to solve extraordinarily complex real-world problems digitally, changing how organizations operate and unlocking significant societal benefits.
• The digital twin is a core metaverse building block. These virtual models simulate real-world objects in detail. The next generation of digital twins will be photorealistic, physics-based, AI-enabled, and linked in metaverse ecosystems.
• The industrial metaverse will transform every industry. Currently existing digital twins illustrate the power and potential of the industrial metaverse to revolutionize design and engineering, testing, operations, and training.
Across social media, a number of creators are generating nostalgic photographs of China with the help of AI. Even though these images get some details wrong, they are realistic enough to trick and impress many of their followers.
The pictures look sophisticated in terms of definition, sharpness, saturation, and color tone. Their realism is partly down to a recent major update of image-making artificial-intelligence program Midjourney that was released in mid-March, which is better not only at generating human hands but also at simulating various photography styles.
It’s still relatively easy, even for untrained eyes, to tell that the photos are generated by an AI. But for some creators, their experiments are more about trying to recall a specific era in time than trying to trick their audience. Read the full story.
—Zeyi Yang
Zeyi’s story is from China Report, his weekly newsletter giving you the inside track on tech in China. Sign up to receive it in your inbox every Tuesday.
Read more of our reporting on AI-generated images:
+ These new tools let you see for yourself how biased AI image models are. Bias and stereotyping are still huge problems for systems like DALL-E 2 and Stable Diffusion, despite companies’ attempts to fix it. Read the full story.