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This woman’s brain implant zaps her with electricity when it senses she’s getting depressed

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This woman’s brain implant zaps her with electricity when it senses she’s getting depressed


Sarah, a 36-year-old woman living in California, had lived with chronic depression for five years. She felt suicidal multiple times an hour and was unable to make decisions about basic questions like what to eat. Nothing she had tried to treat it, including electroconvulsive therapy, had helped.

Then, in June 2020, she had an implant inserted into her skull that zaps the parts of her brain that cause her illness. The remarkable results, published in Nature Medicine today, raise the prospect of personalized treatments for people with severe mental illnesses that don’t respond to therapy or medication.

“My depression has been kept at bay, and that’s allowed me to start rebuilding a life that’s worth living,” Sarah said at a press conference. (Her surname was not given.) 

Installing the device involved multiple steps. First, the team from the University of California, San Francisco, used 10 electrodes to map Sarah’s brain activity. This phase took 10 days, during which time the team found that high levels of activity in a specific part of Sarah’s amygdala predicted the onset of severe depression. They also established that a small burst of electricity to another region of her brain, called the ventral striatum, significantly improved these symptoms. Next, they implanted a neurostimulation device and set it up to trigger a tiny pulse of electricity in that area when it detects high levels of activity associated with depression symptoms. 

Sarah (pictured above) can’t feel these electricity bursts, which is just as well, since they go off up to 300 times a day; each lasts for six seconds. The device doesn’t deliver any zaps at night because they lead to feelings of energy and alertness, which could interfere with Sarah’s ability to sleep.

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The Download: Introducing our TR35 list, and the death of the smart city

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JA22 cover


Spoiler alert: our annual Innovators Under 35 list isn’t actually about what a small group of smart young people have been up to (although that’s certainly part of it.) It’s really about where the world of technology is headed next.

As you read about the problems this year’s winners have set out to solve, you’ll also glimpse the near future of AI, biotech, materials, computing, and the fight against climate change.

To connect the dots, we asked five experts—all judges or former winners—to write short essays about where they see the most promise, and the biggest potential roadblocks, in their respective fields. We hope the list inspires you and gives you a sense of what to expect in the years ahead.

Read the full list here.

The Urbanism issue

The modern city is a surveillance device. It can track your movements via your license plate, your cell phone, and your face. But go to any city or suburb in the United States and there’s a different type of monitoring happening, one powered by networks of privately owned doorbell cameras, wildlife cameras, and even garden-variety security cameras. 

The latest print issue of MIT Technology Review examines why, independently of local governments, we have built our neighborhoods into panopticons: everyone watching everything, all the time. Here is a selection of some of the new stories in the edition, guaranteed to make you wonder whether smart cities really are so smart after all:

– How groups of online neighborhood watchmen are taking the law into their own hands.

– Why Toronto wants you to forget everything you know about smart cities.

– Bike theft is a huge problem. Specialized parking pods could be the answer.

– Public transport wants to kill off cash—but it won’t be as disruptive as you think.

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Toronto wants to kill the smart city forever

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Toronto wants to kill the smart city forever


Most Quayside watchers have a hard time believing that covid was the real reason for ending the project. Sidewalk Labs never really painted a compelling picture of the place it hoped to build. 

Quayside 2.0

The new Waterfront Toronto project has clearly learned from the past. Renderings of the new plans for Quayside—call it Quayside 2.0—released earlier this year show trees and greenery sprouting from every possible balcony and outcropping, with nary an autonomous vehicle or drone in site. The project’s highly accomplished design team—led by Alison Brooks, a Canadian architect based in London; the renowned Ghanaian-British architect David Adjaye; Matthew Hickey, a Mohawk architect from the Six Nations First Nation; and the Danish firm Henning Larsen—all speak of this new corner of Canada’s largest city not as a techno-utopia but as a bucolic retreat. 

In every way, Quayside 2.0 promotes the notion that an urban neighborhood can be a hybrid of the natural and the manmade. The project boldly suggests that we now want our cities to be green, both metaphorically and literally—the renderings are so loaded with trees that they suggest foliage is a new form of architectural ornament. In the promotional video for the project, Adjaye, known for his design of the Smithsonian Museum of African American History, cites the “importance of human life, plant life, and the natural world.” The pendulum has swung back toward Howard’s garden city: Quayside 2022 is a conspicuous disavowal not only of the 2017 proposal but of the smart city concept itself.

To some extent, this retreat to nature reflects the changing times, as society has gone from a place of techno-optimism (think: Steve Jobs introducing the iPhone) to a place of skepticism, scarred by data collection scandals, misinformation, online harassment, and outright techno-fraud. Sure, the tech industry has made life more productive over the past two decades, but has it made it better? Sidewalk never had an answer to this. 

 “To me it’s a wonderful ending because we didn’t end up with a big mistake,” says Jennifer Keesmaat, former chief planner for Toronto, who advised the Ministry of Infrastructure on how to set this next iteration up for success. She’s enthusiastic about the rethought plan for the area: “If you look at what we’re doing now on that site, it’s classic city building with a 21st-century twist, which means it’s a carbon-neutral community. It’s a totally electrified community. It’s a community that prioritizes affordable housing, because we have an affordable-housing crisis in our city. It’s a community that has a strong emphasis on green space and urban agriculture and urban farming. Are those things that are derived from Sidewalk’s proposal? Not really.”

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Rewriting what we thought was possible in biotech

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Rewriting what we thought was possible in biotech


What ML and AI in biotech broadly need to engage with are the holes that are unique to the study of health. Success stories like neural nets that learned to identify dogs in images were built with the help of high-quality image labeling that people were in a good position to provide. Even attempts to generate or translate human language are easily verified and audited by experts who speak a particular language. 

Instead, much of biology, health, and medicine is very much in the stage of fundamental discovery. How do neurodegenerative diseases work? What environmental factors really matter? What role does nutrition play in overall human health? We don’t know yet. In health and biotech, machine learning is taking on a different, more challenging, task—one that will require less engineering and more science.

Marzyeh Ghassemi is an assistant professor at MIT and a faculty member at the Vector Institute (and a 35 Innovators honoree in 2018).

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