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Understanding the mind

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Understanding the mind


Nathan McGee knows a thing or two about having his mind bent. After suffering from PTSD since early childhood, he enrolled in a clinical trial in his 40s to test whether the psychedelic drug MDMA could help him. The result was nothing short of transformative. “I’m seeing life as a thing to be explored and appreciated rather than something to be endured,” he told Charlotte Jee in an intimate interview about his experience. 

Similarly, for those of us experiencing pandemic fatigue, Dana Smith has some good news: our brains definitely took a hit as we social-distanced and Zoomed ourselves into oblivion, but they’re also really, really good at bouncing back. Your pandemic brain will heal; just give it time.

Messing with our heads can also be fun, as Neel Patel tells us. He writes about a talent he developed as a teenager: lucid dreaming. The science behind it is still being worked out, but it’s proving useful for helping people unlock their creativity and deal with fears and traumatic memories.

It is perhaps in dreams where the power of our minds to hold sway over what we believe is “real” is most clearly on display. In a roundup of three fascinating new books on human perception, writer Matthew Hutson quotes one author: “You could even say that we’re all hallucinating all the time. It’s just that when we agree about our hallucinations, that’s what we call reality.”

There’s still the question of what it means to be conscious. For a long time, we humans clung to the idea that we were the only conscious animals. It’s one of several misunderstandings about brains that David Robson and David Biskup put the lie to in comic-strip form. Not only is consciousness hard to define, but it has been extremely difficult to measure. Yet there is now a consciousness meter to detect it in people, as Russ Juskalian finds out. 

Consciousness in silicon form is on Will Douglas Heaven’s brain these days; he ponders whether we’d know it if we managed to build a conscious machine. Dan Falk asks researchers whether they think a brain is a computer in the first place. And Emily Mullin takes a look at two multibillion-dollar efforts to study the human brain in unprecedented detail—one of which involved trying to simulate one from scratch.

No issue on the mind would be complete without a chance to gaze upon the gray matter itself, and there are brains aplenty in our haunting photo essay documenting a library of malformed specimens. If that’s too much, zoom in on our infographic that depicts what happens in Tate Ryan-Mosley’s brain when she sees her boyfriend’s face. And finally, we’ve included a rare treat indeed: a selection of poetry curated by our news editor, Niall Firth. It’s guaranteed to jangle your neurons into a new way of viewing this thing we call “reality.”

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IBM wants to build a 100,000-qubit quantum computer

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The Download: IBM’s quantum ambitions, and tasting lab-grown burgers


Quantum computing holds and processes information in a way that exploits the unique properties of fundamental particles: electrons, atoms, and small molecules can exist in multiple energy states at once, a phenomenon known as superposition, and the states of particles can become linked, or entangled, with one another. This means that information can be encoded and manipulated in novel ways, opening the door to a swath of classically impossible computing tasks.

As yet, quantum computers have not achieved anything useful that standard supercomputers cannot do. That is largely because they haven’t had enough qubits and because the systems are easily disrupted by tiny perturbations in their environment that physicists call noise. 

Researchers have been exploring ways to make do with noisy systems, but many expect that quantum systems will have to scale up significantly to be truly useful, so that they can devote a large fraction of their qubits to correcting the errors induced by noise. 

IBM is not the first to aim big. Google has said it is targeting a million qubits by the end of the decade, though error correction means only 10,000 will be available for computations. Maryland-based IonQ is aiming to have 1,024 “logical qubits,” each of which will be formed from an error-correcting circuit of 13 physical qubits, performing computations by 2028. Palo Alto–based PsiQuantum, like Google, is also aiming to build a million-qubit quantum computer, but it has not revealed its time scale or its error-correction requirements. 

Because of those requirements, citing the number of physical qubits is something of a red herring—the particulars of how they are built, which affect factors such as their resilience to noise and their ease of operation, are crucially important. The companies involved usually offer additional measures of performance, such as “quantum volume” and the number of “algorithmic qubits.” In the next decade advances in error correction, qubit performance, and software-led error “mitigation,” as well as the major distinctions between different types of qubits, will make this race especially tricky to follow.

Refining the hardware

IBM’s qubits are currently made from rings of superconducting metal, which follow the same rules as atoms when operated at millikelvin temperatures, just a tiny fraction of a degree above absolute zero. In theory, these qubits can be operated in a large ensemble. But according to IBM’s own road map, quantum computers of the sort it’s building can only scale up to 5,000 qubits with current technology. Most experts say that’s not big enough to yield much in the way of useful computation. To create powerful quantum computers, engineers will have to go bigger. And that will require new technology.

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How it feels to have a life-changing brain implant removed

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How it feels to have a life-changing brain implant removed


Burkhart’s device was implanted in his brain around nine years ago, a few years after he was left unable to move his limbs following a diving accident. He volunteered to trial the device, which enabled him to move his hand and fingers. But it had to be removed seven and a half years later.

His particular implant was a small set of 100 electrodes, carefully inserted into a part of the brain that helps control movement. It worked by recording brain activity and sending these recordings to a computer, where they were processed using an algorithm. This was connected to a sleeve of electrodes worn on the arm. The idea was to translate thoughts of movement into electrical signals that would trigger movement.

Burkhart was the first to receive the implant, in 2014; he was 24 years old. Once he had recovered from the surgery, he began a training program to learn how to use it. Three times a week for around a year and a half, he visited a lab where the implant could be connected to a computer via a cable leading out of his head.

“It worked really well,” says Burkhart. “We started off just being able to open and close my hand, but after some time we were able to do individual finger movements.” He was eventually able to combine movements and control his grip strength. He was even able to play Guitar Hero.

“There was a lot that I was able to do, which was exciting,” he says. “But it was also still limited.” Not only was he only able to use the device in the lab, but he could only perform lab-based tasks. “Any of the activities we would do would be simplified,” he says. 

For example, he could pour a bottle out, but it was only a bottle of beads, because the researchers didn’t want liquids around the electrical equipment. “It was kind of a bummer it wasn’t changing everything in my life, because I had seen how beneficial it could be,” he says.

At any rate, the device worked so well that the team extended the trial. Burkhart was initially meant to have the implant in place for 12 to 18 months, he says. “But everything was really successful … so we were able to continue on for quite a while after that.” The trial was extended on an annual basis, and Burkhart continued to visit the lab twice a week.

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The Download: brain implant removal, and Nvidia’s AI payoff

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A brain implant changed her life. Then it was removed against her will.


Leggett told researchers that she “became one” with her device. It helped her to control the unpredictable, violent seizures she routinely experienced, and allowed her to take charge of her own life. So she was devastated when, two years later, she was told she had to remove the implant because the company that made it had gone bust.

The removal of this implant, and others like it, might represent a breach of human rights, ethicists say in a paper published earlier this month. And the issue will only become more pressing as the brain implant market grows in the coming years and more people receive devices like Leggett’s. Read the full story.

—Jessica Hamzelou

You can read more about what happens to patients when their life-changing brain implants are removed against their wishes in the latest issue of The Checkup, Jessica’s weekly newsletter giving you the inside track on all things biotech. Sign up to receive it in your inbox every Thursday.

If you’d like to read more about brain implants, why not check out:

+ Brain waves can tell us how much pain someone is in. The research could open doors for personalized brain therapies to target and treat the worst kinds of chronic pain. Read the full story.

+ An ALS patient set a record for communicating via a brain implant. Brain interfaces could let paralyzed people speak at almost normal speeds. Read the full story.

+ Here’s how personalized brain stimulation could treat depression. Implants that track and optimize our brain activity are on the way. Read the full story.

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